ALEFACEPT Resources

    ALEFACEPT U.S. Government resources:
    Alefacept - Product Approval Information - Licensing Action: Alefacept - Product Approval Information - Licensing Action.
    http://www.fda.gov/ohrms/dockets/ac/02/slides/3865S1_01_FDA-Bonvini/sld003.htm

    Alefacept: First Previous Next Last Index Text. Slide 3 of 8.
    http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/500465.html

    MedlinePlus Drug Information: Alefacept (Systemic): For alefacept the following should be considered:. Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to alefacept.
    http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a603011.html

    MedlinePlus Drug Information: Alefacept Injection: Alefacept is used to treat moderate to severe chronic plaque psoriasis. Alefacept is in a class of immunosuppressant medications called dimeric fusion
    http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?holding=npg&cmd=Retrieve&db=PubMed&list_uids=12384938&dopt=Abstract

    Alefacept treatment in psoriatic arthritis: reduction of the ...: OBJECTIVE: To investigate whether alefacept (a fully human lymphocyte ... METHODS: Eleven patients with active PsA were treated with alefacept for 12
    http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?holding=npg&cmd=Retrieve&db=PubMed&list_uids=14667953&dopt=Abstract

    An overview of infliximab, etanercept, efalizumab, and alefacept ...: In a Phase III trial of IM alefacept 15 mg once weekly for 12 weeks, ... of the efficacy and tolerability of once-weekly alefacept 7.5 mg via IV bolus,
    http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=545584&rendertype=abstract

    Alefacept reduces infiltrating T cells, activated dendritic cells ...: Because we observed that alefacept binds primarily to T cells and not DCs, we suggest that T cells are the primary target for therapy, but that DCs and
    http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=545584

    Alefacept reduces infiltrating T cells, activated dendritic cells ...: Because we observed that alefacept binds primarily to T cells and not DCs, ... The study of alefacept's mechanism is difficult, as this fusion protein
    http://www.cms.hhs.gov/mcd/index_local_alpha.asp?from=alphalmrp&letter=A

    Centers for Medicare & Medicaid Services: ...view details L12842, Alefacept Therapy. view details L12918, Alefacept Therapy ... view details DL17635, Alefacept Therapy
    http://www.4woman.gov/News/English/516537.htm

    2003.12.16 -- Soothing News for Psoriasis Sufferers: ...of intravenous alefacept on T-cell levels and the severity of psoriasis. ... subsets with alefacept treatment correlates to improvement in psoriasis and
    https://www.cms.hhs.gov/mcd/index_local_alpha.asp?from=alphalmrp&letter=A

    Centers for Medicare & Medicaid Services: ...view details L13834, Amevive for Injection (Alefacept). view details L3626, AMIFOSTINE. view details L8928, Amifostine (Ethyol)
    http://www.pueblo.gsa.gov/cic_text/health/psoriasis/psoriasis.htm

    FCIC: Questions and Answers About Psoriasis: ...a group of drugs called biologics (for example, alefacept and etanercept), ... Because alefacept suppresses the immune system, the skin often improves,
    http://www.guidelines.gov/summary/summary.aspx?doc_id=5670&mode=full&ss=15

    Psoriasis.: ...and sulfasalazine; Biologicals, such as alefacept, efalizumab, etanercept, and infliximab ... Alefacept and efalizumab inhibit T-cell activation.
    http://www.guidelines.gov/summary/summary.aspx?doc_id=5670

    Psoriasis.: Biologicals, such as alefacept, efalizumab, etanercept, and infliximab, have recently been ... Alefacept and efalizumab inhibit T-cell activation.
    http://www.visn20.med.va.gov/webRx/restrfile.html?restr=AcetylcysteineIV

    VISN 20 Formulary - Restrictions: Alefacept, etanercept, efalizumab and infliximab are non-formulary for the treatment of severe psoriasis or psoriatic arthritis, restricted to
    http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/psn/transcript.cfm?show=14

    Academic resources:

    UMHS News - Alefacept Approval: Alefacept, a specially designed molecule that blocks a specific immune-system reaction involved in the painful skin condition, was approved for marketing today ...
    http://www.med.umich.edu/opm/newspage/2001/psoriasis.htm

    UMHS News Release: Health System and the University of Utah Health Sciences Center report the promising results of a clinical trial of a unique targeted therapy called alefacept. ...
    http://www.med.miami.edu/glossary/art.asp?articlekey=22865

    University of Miami School of Medicine - Glossary - alefacept ...: Medications and Prescriptions >>. alefacept, Amevive. Pharmacy Author: Omudhome ... GENERIC NAME: alefacept. BRAND NAME: Amevive. DRUG CLASS AND ...
    http://uuhsc.utah.edu/pharmacy/bulletins/alefacept.html

    Alefacept (Amevive): Alefacept (Amevive®), < Print >. Date ... adults. Alefacept interferes with lymphocyte activation through binding to the CD2 lymphocyte antigen. ...
    http://www.hopkins-arthritis.som.jhmi.edu/edu/eular2003/ra-treatments-tcell.html

    Johns Hopkins Arthritis Presents Highlights from EULAR 2003: OP0111 A PILOT STUDY OF THE SAFETY AND EFFICACY OF ALEFACEPT IN SUBJECTS WITH ACTIVE RHEUMATOID ARTHRITIS ON METHOTREXATE M Schneider, H Stahl, AK Vaishnaw, T ...
    http://www.wpunj.edu/pa/2-25.htm

    Psoriatic Arthritis List NEWSLETTER: EARLY RESULTS SUGGEST ALEFACEPT PLUS LIGHT THERAPY MAY CLEAR PSORIASIS Cambridge, MA - November 22, 2002. ...
    http://www.wpunj.edu/pa/4-02.htm

    Psoriatic Arthritis List NEWSLETTER: Editors note: The following information is provided for those readers who want to discuss the use of AMEVIVE (Alefacept) with their health care specialists. ...
    http://www-cme.erep.uab.edu/onlineCourses/uab_insight/summer04/psoriasis/ID0211.htm

    Online CME: Both agents, alefacept (Amevive) and efalizumab (Raptiva), modulate T-cell function. ... A review of key clinical trials of alefacept (J Am Acad Dermatol. ...
    http://www-cme.erep.uab.edu/onlineCourses/Psoriasis/ID0204.html

    Online CME: The most common ones currently being used in the treatment of psoriasis are etanercept, alefacept, and efalizumab. ... Alefacept (Amevive). ...
    http://www.healthsystem.virginia.edu/uvahealth/news_menshealth/0308mh.cfm

    Men''s Health - August 2003: Alefacept (called Amevive®), is widely considered by experts to be a breakthrough drug. A study in the Archives of Dermatology ...
    http://rwjms.umdnj.edu/medicine/divisions/clinical_pharmacology/studies.htm

    Robert Wood Johnson Medical School: Investigator-Initiated. Gottlieb. Lipets. Alefacept. Psoriasis. PEDS 211. Enrolling. Amgen. ... Gottlieb. Lozano. Cyclosporine/Alefacept. Psoriasis. Vitiligo. Enrolling ...
    http://www.gcrc.uci.edu/studies/index.cfm

    UCI GCRC Home Page: Placebo-Controlled, Double-Blind, Multicenter Study Examining the Efficacy and Safety of Weekly Intramuscular Administration of 15mg Alefacept Over 12 Weeks in ...
    http://healthlink.mcw.edu/article/926054522.html

    The Facts about Psoriasis: ...defects. Alefacept (Amevive). This is the first biologic drug approved specifically to treat moderate to severe plaque psoriasis. ...
    http://www.umm.edu/patiented/articles/what_systemic_treatments_psoriasis_000087_8.htm

    Psoriasis - UMMC: ...this worry. T-Cells-Blockers. Alefacept (Amevive) blocks overactive T-cells but appears to leave other immune factors alone. It has ...
    http://lifesci.rutgers.edu/~molbiosci/Professors/gottlieb.html

    Alice Bendix Gottlieb: HD, Roberts JL, Washenik K, Vaishnaw A, Gordon KB: Primary and secondary immune responses are maintained in psoriatic patients receiving alefacept: Results of ...
    http://www.rx.uga.edu/main/home/phrm5920/2003_fall/table_f03.htm



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