ALTEPLASE Resources

    ALTEPLASE U.S. Government resources:
    Alteplase - Product Approval Information - Licensing Action: Alteplase - Product Approval Information - Licensing Action.
    http://www.fda.gov/bbs/topics/ANSWERS/ANS00653.html

    FDA APPROVES NEW REGIMEN FOR ALTEPLASE: ...about the approval of an accelerated infusion regimen for alteplase, ... The new dosing regimen calls for intravenous administration of alteplase to
    http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1975321&dopt=Abstract

    GISSI-2: a factorial randomised trial of alteplase versus ...: 1.5 MU infused intravenously over 30-60 min) and alteplase (tPA, 100 mg infused intravenously over 3 h) in patients with acute myocardial infarction
    http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12374874&dopt=Abstract

    Heparin plus alteplase compared with heparin alone in patients ...: ...plus 100 mg of alteplase or heparin plus placebo over a period of two hours. ... receive heparin plus alteplase and 138 to receive heparin plus placebo.
    http://www.clinicaltrials.gov/ct/gui/show/NCT00082355

    Clinical Trial: Low-Dose Alteplase to Treat Blood Clots in Deep ...: Thrombosis of the Lower Extremities with "Low-Dose" Alteplase: a Pilot Study ... even more effective by using a substantially lower dose of alteplase.
    http://www.clinicaltrials.gov/ct/show/NCT00103766

    Clinical Trial: Alteplase for Treatment of Empyema and Complicated ...: ...effusion (CPE) using a daily versus twice daily Alteplase regimen of two ... Current or pre-existing bleeding dyscrasia; Known allergy to Alteplase
    http://www.cancer.gov/Templates/db_alpha.aspx?CdrID=377725

    National Cancer Institute - Dictionary of Cancer Terms: Alteplase belongs to the family of drugs called systemic thrombolytic agents. Also called tissue plasminogen activator (tPA), recombinant tissue
    http://www.cancer.gov/Templates/db_alpha.aspx?print=1&cdrid=377725

    National Cancer Institute - Dictionary of Cancer Terms: Alteplase ... It is also being studied in the treatment of cancer. Alteplase belongs to the family of drugs called systemic thrombolytic agents.
    http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/202565.html

    MedlinePlus Drug Information: Thrombolytic Agents (Systemic): Studies on birth defects with alteplase and anistreplase have not been done in either ... Your doctor may decide to use alteplase or urokinase instead.
    http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=80367

    Reactions to alteplase in patients with acute thrombotic stroke: Reactions to alteplase in patients with acute thrombotic stroke. William B. Chodirker. Allergist and clinical immunologist London Health Sciences Centre
    http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=29099&rendertype=abstract

    Symptomatic hemorrhage after alteplase therapy not due to silent ...: He was treated with intravenous alteplase and underwent extensive early imaging with multimodal MRI. Several hours after treatment he developed a
    http://www.cc.nih.gov/phar/updates/99nov-dec.html

    Pharmacy Update, September / October 1999: Both streptokinase and alteplase have been used to restore patency of ... The results of several published clinical studies suggest that alteplase may
    http://www.guidelines.gov/summary/summary.aspx?view_id=1&doc_id=5898

    Thrombolysis and adjunctive therapy in acute myocardial infarction ...: ...the guideline developers recommend the administration of alteplase or tenecteplase ... For patients receiving alteplase, tenecteplase, or reteplase for
    http://www.guidelines.gov/summary/summary.aspx?ss=15&doc_id=5898&nbr=3884

    Thrombolysis and adjunctive therapy in acute myocardial infarction ...: Cost-effectiveness of Alteplase in Comparison to Streptokinase ... At 1 year, alteplase-treated patients had both higher costs ($2845) and higher
    http://www.4woman.gov/News/English/518462.htm

    2004.04.22 -- Three Drugs Equal With DVT: ...safety and cost of three drugs -- urokinase, alteplase and reteplase. ... Alteplase was 13 times less expensive than urokinase and four times cheaper
    http://www.oqp.med.va.gov/cpg/IHD/IHD_CPG/content/moduleA/IHDModA_H_anno.htm

    Module A, Annotation H:Are There Contraindications To Thrombolysis?: Use of alteplase; Excessive anticoagulation (ie, INR >4; APTT >24) ... prior stroke, admission systolic blood pressure >160 mmHg, use of alteplase,
    http://www.healthfinder.gov/news/newsstory.asp?docID=518462

    Academic resources:

    University of Miami School of Medicine - Glossary - alteplase ...: ...alteplase, Activase, TPA. GENERIC NAME: alteplase. ... Alteplase is an enzyme that occurs naturally in man and causes blood clots to dissolve. ...
    http://www.umm.edu/ency/article/007089.htm

    Thrombolytic therapy (tissue plasminogen activator - tPA): Alternative Names: TPA; Alteplase; Reteplase; Tenecteplase; Activase thrombolytic agent; Clot-dissolving agents; Reperfusion therapy. Information: ...
    http://www.umm.edu/patiented/articles/thrombolytic_drugs_used_restore_blood_flow_after_a_heart_attack_000012_7.htm

    Heart Attack - UMMC: ...muscle tissue death. Specific Thrombolytics. The current standard thrombolytic drug is t-PA or alteplase (Activase). Others used ...
    http://www.cpb.uokhsc.edu/fda/ans/ans00654.html

    FDA Answers: T95-18 Monica Revelle April 3, 1995 (301) 443-4177 FDA APPROVES NEW REGIMEN FOR ALTEPLASE. ... In 1990, alteplase was also approved for pulmonary embolism. ...
    http://intmedweb.wfubmc.edu/cat_bites/rpa.html

    Reteplase did not improve survival when compared to alteplase in ...: Reteplase did not improve survival when compared to alteplase in the treatment of acute myocardial infarction. ... Time to Outcome. Alteplase. (n=4921). Reteplase. ...
    http://www.baylorhealth.edu/proceedings/14_1/14_1_song.html

    Usefulness of catheter-directed thrombolysis using altepase in ...: BUMC Proceedings 2001;14:3-7. Usefulness of catheter-directed thrombolysis using alteplase in peripheral vascular occlusion. ... Alteplase, Lysis, Complications. ...
    http://www2.umdnj.edu/~shindler/trials/trials_r.html

    Clinical Trials in Cardiology: RAAMI Randomized Angiographic trial of Alteplase in Myocardial Infarction. RAAMI Rapid Administration of Alteplase in Myocardial ...
    http://faculty.washington.edu/momus/PB/mimrp.htm

    Dr. Rose's Peripheral Brain-ACUTE MI AND OTHER ACUTE CORONARY ...: Alteplase (100mg accelerated-dose) Abciximab 0.24mg/kg bolus plus 0.125mg/kg/min x 12h Abciximab + low-dose Alteplase (20-65mh) Abciximab + low-dose ...
    http://www.emory.edu/WHSCL/grady/amreport/litsrch98/p990120b.html

    p990120b - Pulmonary Embolism, Treatement with Anticoagulants: Title: Comparison of alteplase versus heparin for resolution of major pulmonary embolism. Source: American Journal of Cardiology. 82(8):966-70, 1998 Oct 15. ...
    http://fred.hmc.psu.edu/ds/retrieve/fred/meshdescriptor/D010959

    Penn State Faculty Research Expertise Database (FRED): EC 3.4.21.68. Related Terms, Alteplase, Plasminogen Activator, Tissue-Type. ... Actilyse, Activase. Boehringer Ingelheim Brand of Alteplase, Genentech Brand of Alteplase ...
    http://vigour.dcri.duke.edu/trials.html

    VIGOUR Trials: ASSENT-II This recent trial of 17,000 patients with acute myocardial infarction showed that tenecteplase (TNK) can be as effective as alteplase (t-PA) in ...
    http://www.ucsf.edu/its/listserv/emed-l/6794.html



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